Perimenopause Support

Peptides for Perimenopause: Navigate the Change

You don't have to just "deal with it." Peptides offer targeted support for the symptoms that disrupt your life - hot flashes, weight gain, fatigue, brain fog, and more. A natural approach to an often challenging transition.

Shop Menopause Support Hormone Guide

Understanding Perimenopause

Perimenopause is the transition phase before menopause, typically starting in your early to mid-40s and lasting 4-10 years. During this time, estrogen and progesterone fluctuate wildly, growth hormone continues its decline, and your body adapts to a new hormonal reality.

The symptoms are real and disruptive: hot flashes that wake you at 3 AM, weight that won't budge despite diet and exercise, energy crashes, brain fog that makes you forget why you walked into a room, mood swings that strain relationships.

Traditional HRT addresses estrogen and progesterone, but many women can't or won't use it. Peptides offer a different approach - supporting your body's own production of growth hormone, NAD+, and other factors that decline with age. They can work alongside HRT or as an alternative.

[Perimenopause Timeline Infographic]

Image: Timeline showing perimenopause phases and symptoms

Common Symptoms & Peptide Solutions

Match your symptoms to targeted peptide support

Hot Flashes

Sermorelin, HGH

Hormone regulation

Weight Gain

Semaglutide, AOD-9604

Metabolism support

Low Energy

NAD+, HGH

Cellular energy production

Brain Fog

NAD+, Ipamorelin

Cognitive support

Poor Sleep

Sermorelin, Ipamorelin

Sleep cycle regulation

Low Libido

HGH, PT-141

Hormone & desire support

Mood Changes

Sermorelin, NAD+

Hormone balance

Dry Skin

Collagen, HGH

Skin hydration

The Perimenopause Peptide Protocol

Build your personalized stack based on your symptoms

START HERE

Foundation Stack

The essential peptides for perimenopause support

Sermorelin

200mcg nightly

Hormone support, sleep, mood

NAD+

150mg 2-3x weekly

Energy, cognition, cellular health

Collagen

10g daily (oral)

Skin, joints, gut health

ADD-ON

Weight Management Add-On

For stubborn menopausal weight gain

Semaglutide OR TirzepatideStart low, titrate up

Appetite control, fat loss

AOD-9604 (optional)250-300mcg daily

Targets visceral fat

Weight Loss Guide

ADD-ON

Sleep Support Add-On

For sleep disturbances and night sweats

Ipamorelin200mcg before bed

Deep sleep, GH release

CJC-1295 (no DAC)100mcg with Ipamorelin

Extended GH support

Hormone Guide

Peptides vs. Traditional HRT

Understanding your options - many women use both

Factor	Peptides	Traditional HRT
Approach	Stimulate natural production	Replace hormones directly
Breast Cancer Risk	Not associated	Slightly increased
Blood Clot Risk	Not associated	Slightly increased
Effectiveness	Moderate-high	High
Doctor Required	Sometimes	Yes
Cost	$$-$$$	$-$$
Targets	GH, energy, metabolism	Estrogen, progesterone

Note: This isn't medical advice. Many women use peptides alongside or instead of HRT. The right choice depends on your individual health history, risk factors, and symptoms. Always consult your healthcare provider.

Real Women, Real Results

Experiences from women navigating perimenopause with peptide support

"At 48, I thought feeling exhausted was just my new normal. After 3 months on sermorelin and NAD+, I have energy I haven't felt in years. The brain fog lifted and I'm sleeping through the night again."

Sarah, 48

"The weight kept creeping on no matter what I did. Adding semaglutide to my routine finally broke through the plateau. Down 25 lbs and my hot flashes have almost disappeared."

Michelle, 52

"I was skeptical about peptides but desperate. HRT wasn't an option for me due to family history. Ipamorelin and collagen have given me my skin and sleep back. Wish I'd started sooner."

Jennifer, 50

*Results vary by individual. These testimonials represent individual experiences.

Frequently Asked Questions

Can I use peptides with HRT (Hormone Replacement Therapy)?

Many women do. Peptides work on different pathways (primarily growth hormone) than HRT (estrogen/progesterone). Some use peptides as an alternative to HRT, others as a complement. Peptides can address symptoms HRT doesn't fully resolve, like energy and metabolism. Always discuss with your healthcare provider.

How long until perimenopause symptoms improve?

Sleep and energy often improve within 2-4 weeks. Hot flashes may reduce in 4-6 weeks. Weight loss and mood stabilization typically take 1-3 months. Consistency is key - give peptides at least 3 months before judging full effects.

Are peptides safe long-term for menopause support?

Current evidence suggests yes for most peptides, especially growth hormone secretagogues like sermorelin and ipamorelin. They've been studied for decades with good safety profiles. NAD+ and collagen are naturally occurring substances. Always monitor with your healthcare provider and get regular blood work.

Will peptides help with vaginal dryness?

HGH peptides can improve overall tissue health and may help indirectly. However, local estrogen therapy is typically more effective for vaginal symptoms specifically. Peptides are better for systemic symptoms like energy, metabolism, sleep, and mood.

What age should I start using peptides for perimenopause?

Most women enter perimenopause between 40-45, though it can start earlier. If you're experiencing symptoms - irregular periods, hot flashes, sleep changes, weight gain - it may be time to consider peptides. Some women start "preventatively" in their late 30s with gentler peptides like sermorelin.

Can peptides delay menopause?

Peptides don't delay menopause itself (the end of menstruation), but they can significantly reduce symptoms and help you feel more like yourself during the transition. They support your body's ability to adapt to changing hormone levels.

Take Control of Your Transition

Perimenopause doesn't have to derail your life. Start with the foundation stack and adjust based on your symptoms.

Shop Perimenopause Support Weight Loss Guide