What is Retatrutide?
Retatrutide is a next-generation triple-agonist peptide that targets three key receptors: GLP-1, GIP, and glucagon. This unique triple action makes it one of the most promising compounds for weight loss and metabolic health, with clinical trials showing up to 24% body weight reduction over 48 weeks.
Key Benefits:
- Significant appetite suppression
- Enhanced fat burning through glucagon activation
- Improved glucose regulation
- Once-weekly dosing convenience
Reconstitution Guide
What You'll Need
- Retatrutide 10mg vial (lyophilized powder)
- Bacteriostatic water (BAC water)
- Insulin syringes (1mL/100 unit)
- Alcohol swabs
- Clean workspace
Step-by-Step Mixing Instructions
- Prepare your workspace - Clean the area and wash your hands thoroughly
- Warm to room temperature - Allow both the peptide vial and BAC water to reach room temperature before mixing
- Clean the vial tops - Swab both vial tops with alcohol and let dry
- Draw the BAC water - For a 10mg vial, draw 2mL (200 units) of bacteriostatic water
- Inject slowly - Insert needle into the Retatrutide vial and inject water slowly down the inside wall of the vial (not directly onto the powder)
- Swirl gently - DO NOT SHAKE. Gently swirl the vial in circles until the powder is completely dissolved
- Inspect - The solution should be clear with no particles or cloudiness
Resulting Concentration: 10mg in 2mL = 5mg/mL (5000mcg/mL)
Dosing Protocol
Retatrutide requires a gradual dose escalation to minimize side effects. Do not skip ahead in the titration schedule.
Titration Schedule
| Week | Dose | Volume (with 2mL reconstitution) |
|------|------|----------------------------------|
| 1-4 | 1mg | 0.2mL (20 units) |
| 5-8 | 2mg | 0.4mL (40 units) |
| 9-12 | 4mg | 0.8mL (80 units) |
| 13-16 | 6mg | 1.2mL (120 units)* |
| 17-20 | 8mg | 1.6mL (160 units)* |
| 21+ | 8-12mg | Maintenance dose |
*For doses requiring more than 1mL, you may need to split into two injections or reconstitute with less water.
Alternative Reconstitution for Higher Doses
If you plan to reach maintenance doses of 8-12mg, consider reconstituting with only 1mL of BAC water for a concentration of 10mg/mL. This allows larger doses in a single injection.
Dosing Schedule
- Frequency: Once weekly (every 7 days)
- Same day each week: Pick a day and stick to it
- Missed dose: If within 5 days, take it. If more than 5 days late, skip and resume next scheduled dose
Injection Guide
Injection Sites
Rotate between these subcutaneous injection sites:
- Abdomen - 2 inches away from the navel (most common)
- Thigh - Front or outer thigh
- Upper arm - Back of the arm
Rotate sites weekly to prevent tissue irritation and lipodystrophy.
Injection Technique
- Clean the injection site with an alcohol swab
- Pinch a fold of skin
- Insert the needle at a 45-90 degree angle
- Inject slowly and steadily
- Hold for 5-10 seconds before withdrawing
- Do not rub the injection site
Storage Instructions
Lyophilized (Powder) Form
- Short-term (1-2 months): Refrigerate at 2-8°C (36-46°F)
- Long-term: Freeze at -20°C (-4°F)
- Protect from light and moisture
Reconstituted Solution
- Refrigerate immediately at 2-8°C (36-46°F)
- Use within 4-6 weeks of reconstitution
- Never freeze reconstituted solution
- Keep away from light
- Discard if solution becomes cloudy or contains particles
Managing Side Effects
Common Side Effects
The most common side effects are gastrointestinal and typically occur during dose escalation:
- Nausea (most common)
- Decreased appetite
- Diarrhea or constipation
- Mild abdominal discomfort
Tips to Minimize Side Effects
For Nausea:
- Eat smaller, more frequent meals
- Avoid greasy, fatty, and spicy foods
- Stay well hydrated
- Try ginger tea or mint tea
- Eat bland foods (bananas, rice, toast)
- Avoid eating large meals late at night
General Tips:
- Follow the titration schedule strictly
- Don't increase dose if still experiencing significant side effects
- Stay hydrated (drink plenty of water)
- Avoid alcohol, especially during dose increases
When Side Effects Typically Improve
- Most GI symptoms fade after 8-12 weeks
- Symptoms may briefly return when increasing doses
- Side effects are usually mildest at stable maintenance doses
What to Expect
Week 1-2
- Mild appetite suppression begins
- May feel full sooner than usual
- Some users experience mild nausea
- Allow your body time to adjust
Week 4-8
- Appetite suppression becomes more noticeable
- Weight loss typically begins
- Side effects often peak during dose increases
- Energy levels may improve
Week 12+
- Significant appetite reduction
- Consistent weight loss
- Side effects typically stabilize
- Improved metabolic markers
Important Warnings
Seek immediate medical attention if you experience:
- Severe, persistent abdominal pain (may indicate pancreatitis)
- Signs of allergic reaction (rash, difficulty breathing, swelling)
- Severe vomiting that won't stop
- Signs of low blood sugar (shakiness, sweating, confusion)
Contraindications:
- Personal or family history of medullary thyroid carcinoma
- Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- History of pancreatitis
- Pregnancy or breastfeeding
Stacking Considerations
Retatrutide may be used alongside:
- NAD+ - For enhanced cellular energy and metabolism
- BPC-157 - For gut health support (may help with GI side effects)
Note: Always consult with a healthcare provider before combining compounds.
Research Disclaimer
Retatrutide is an investigational compound currently in Phase 3 clinical trials. It has not been approved by the FDA for any indication. This guide is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting any new supplement or medication regimen.
